THE BEST SIDE OF PKRRATING

The activated enzyme then phosphorylates its big substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to a conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to diverse stimuli12, triggering the integrated worry response1